Emilio Perucca Selected Research

Drug Resistant Epilepsy

1/2022	Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy.
12/2019	Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.
1/2019	Novel therapies for epilepsy in the pipeline.
8/2011	Antiepileptic drug therapy: does mechanism of action matter?
3/2011	Addressing overtreatment in patients with refractory epilepsy at a tertiary referral centre in Brazil.
10/2010	Patterns of prescription of antiepileptic drugs in patients with refractory epilepsy at tertiary referral centres in Italy.
6/2010	Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
5/2010	Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: reply to Beyenburg et al., 2009.
5/2010	Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug-refractory epilepsy.
2/2006	The ketogenic diet: from molecular mechanisms to clinical effects.

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Emilio Perucca Research Topics

Disease

99	Epilepsy (Aura) 05/2024 - 01/2002
54	Seizures (Absence Seizure) 11/2023 - 01/2002
18	Partial Epilepsies (Epilepsy, Partial) 11/2023 - 11/2003
12	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2023 - 04/2011
12	Drug Resistant Epilepsy 01/2022 - 01/2003
9	Lennox Gastaut Syndrome 01/2023 - 07/2008
5	Brain Diseases (Brain Disorder) 12/2023 - 01/2002
5	Epileptic Syndromes 01/2021 - 01/2003
5	Congenital Abnormalities (Deformity) 01/2020 - 11/2005
4	Absence Epilepsy (Childhood Absence Epilepsy) 01/2017 - 05/2010
4	Body Weight (Weight, Body) 01/2016 - 04/2004
3	Fatigue 12/2023 - 11/2011
3	Tuberous Sclerosis (Bourneville's Disease) 01/2022 - 01/2019
3	COVID-19 01/2022 - 01/2020
3	Status Epilepticus (Complex Partial Status Epilepticus) 06/2011 - 01/2002
2	Sleepiness 09/2019 - 11/2011
2	Cognitive Dysfunction 01/2019 - 11/2015
2	Dementia (Dementias) 01/2018 - 01/2018
2	Generalized Epilepsy 09/2015 - 10/2014
2	Spontaneous Abortion (Miscarriage) 08/2015 - 07/2011
2	Brain Neoplasms (Brain Tumor) 12/2013 - 02/2002
2	Malformations of Cortical Development 02/2008 - 04/2007
2	Schizophrenia (Dementia Praecox) 10/2006 - 08/2002
1	Weight Gain 12/2023
1	Laryngitis 12/2023
1	Respiratory Tract Infections (Respiratory Tract Infection) 12/2023
1	Temporal Lobe Epilepsy 01/2023
1	Weight Loss (Weight Reduction) 10/2021
1	Hypohidrosis 01/2021
1	Fever (Fevers) 01/2021

Drug/Important Bio-Agent (IBA)

77	Anticonvulsants (Antiepileptic Drugs)IBA 01/2024 - 01/2002
18	Valproic Acid (Depakote)FDA LinkGeneric 01/2021 - 01/2002
15	Carbamazepine (Tegretol)FDA LinkGeneric 08/2015 - 01/2002
12	Lamotrigine (Lamictal)FDA LinkGeneric 01/2016 - 01/2006
11	Levetiracetam (Keppra)FDA LinkGeneric 01/2022 - 03/2005
10	Phenobarbital (Luminal)FDA Link 01/2023 - 01/2002
8	perampanelIBA 10/2021 - 01/2013
8	Phenytoin (Dilantin)FDA LinkGeneric 03/2013 - 01/2002
6	Topiramate (Topamax)FDA LinkGeneric 01/2021 - 06/2003
5	Lacosamide FDA Link 01/2022 - 12/2008
5	CannabidiolIBA 01/2022 - 10/2018
5	Vigabatrin FDA Link 11/2009 - 01/2006
4	Clobazam (HR 376)IBA 12/2023 - 09/2019
4	FenfluramineIBA 01/2023 - 11/2020
4	Oxcarbazepine (Trileptal)FDA LinkGeneric 01/2022 - 01/2006
4	EnzymesIBA 12/2019 - 12/2003
3	CenobamateIBA 01/2023 - 11/2020
3	gamma-Aminobutyric Acid (GABA)IBA 01/2023 - 04/2007
3	rufinamide FDA Link 01/2020 - 07/2008
3	Pregabalin (Lyrica)FDA Link 08/2009 - 01/2006
3	Gabapentin (Neurontin)FDA LinkGeneric 07/2006 - 02/2003
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2023 - 11/2020
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2023 - 01/2023
2	NorfenfluramineIBA 01/2023 - 10/2021
2	Antisense OligonucleotidesIBA 01/2023 - 01/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2023 - 01/2023
2	Peptides (Polypeptides)IBA 01/2023 - 01/2019
2	BenzodiazepinesIBA 01/2023 - 01/2006
2	Ethosuximide (Zarontin)FDA LinkGeneric 01/2021 - 03/2013
2	Biomarkers (Surrogate Marker)IBA 11/2020 - 11/2015
2	SolutionsIBA 11/2020 - 10/2018
2	AcidsIBA 12/2016 - 01/2013
2	Zonisamide (Zonegran)FDA LinkGeneric 03/2013 - 01/2006
2	eslicarbazepine acetateIBA 11/2011 - 04/2011
2	Genetic Markers (Genetic Marker)IBA 04/2009 - 01/2003
2	Risperidone (Risperdal Consta)FDA LinkGeneric 10/2006 - 08/2002
1	Potassium Channels (Potassium Channel)IBA 11/2023
1	KCNQ3 Potassium ChannelIBA 11/2023
1	XEN1101IBA 11/2023
1	NRP2945IBA 01/2023
1	NeurosteroidsIBA 01/2023
1	Alprazolam (Xanax)FDA LinkGeneric 01/2023
1	Antiparasitic Agents (Antiparasitics)IBA 01/2023
1	Bumetanide (Bumex)FDA LinkGeneric 01/2023
1	DiureticsIBA 01/2023
1	Ivermectin (Mectizan)FDA Link 01/2023
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2022
1	ganaxoloneIBA 11/2022
1	lorcaserinIBA 01/2022
1	Apoptosis Regulatory ProteinsIBA 01/2022
1	Free RadicalsIBA 01/2022
1	5-HT2C Serotonin ReceptorIBA 01/2022
1	nirmatrelvirIBA 01/2022
1	CytochromesIBA 01/2022
1	Ritonavir (Norvir)FDA Link 01/2022
1	Clonazepam (Rivotril)FDA LinkGeneric 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	Adenosine (Adenocard)FDA LinkGeneric 01/2021
1	AutoantibodiesIBA 11/2020
1	Prednisolone (Predate)FDA LinkGeneric 11/2020
1	Methylprednisolone FDA LinkGeneric 11/2020

Therapy/Procedure

40	Therapeutics 11/2023 - 11/2002
6	Drug Therapy (Chemotherapy) 01/2023 - 07/2002
5	Precision Medicine 01/2022 - 10/2015
2	Ketogenic Diet 01/2019 - 02/2006
2	Vagus Nerve Stimulation 01/2019 - 06/2014
1	Cesarean Section (Caesarean Section) 05/2024
1	Postnatal Care 05/2024
1	Induced Labor 05/2024
1	Investigational Therapies (Experimental Therapy) 01/2023